Gustavo Sato dos Santos
Imaging Epileptic Seizures in a Rat Model using Electric Impedance Tomography and its Clinical Implications2014-04-24The potential of Electric Impedance Tomography (EIT) for localising seizure foci was examined in a rat model of epilepsy. The known seizure focus was successfully imaged, which appeared as a transient (~10 ms) decrease in impedance during spikes – due to the opening of ion channels, followed by a gradual increase in impedance as cells swelled.
2014-04-24EIT has much potential in many brain imaging applications demonstrated through animal experiments with a small epicortical 30-channel array. Spatial resolution can be improved by using a larger array to cover most of brain. A 120-channel electrode system was fabricated and successfully implanted covering c.90% of brain, and EIT data was successfully recorded.
2014-04-24We present the first EIT images of evoked physiological activity in the primary somatosensory cortex (S1) obtained with intracranial planar electrode array. Images were validated using intrinsic signal optical imaging (ISOI) and current source-sink density analysis (CSDA). Detailed high-resolution spatiotemporal connectivity of the brain cortex was reconstructed with ≤200μm and ≤2ms.